【个人简介】

曹建，博士，副研究员，硕士生导师。2010年6月于浙江大学获博士学位；2010年7月加入杭州师范大学有机硅化学及材料技术教育部重点实验室，目前主要从事有机合成方法学和有机硅化学的基础和应用研究。先后主持和参与了国家自然科学基金、浙江省自然科学基金和杭州市科技项目。已在Angew. Chem. Int. Ed.; Coord. Chem. Rev.; Chem. Commun.; Org. Lett.; Adv. Synth. Catal.等权威期刊上发表学术论文30余篇；其中多篇论文入选Synfacts。指导研究生多次获得国家奖学金和经亨颐奖学金。

【主要学习经历】

2005.9~2010.6 浙江大学，博士（导师：黄宪院士）；

2017.10~2018.10 瑞士洛桑联邦理工学院，访问学者（合作教授：祝介平教授）。

【主要研究方向】

1. 过渡金属催化的不对称合成方法研究；

2. 小环化合物的合成和反应研究；

3. 有机硅化合物的合成和反应研究；

【主要主持科研项目】

1．设计通过官能化联烯中间体的串联反应合成环状化合物，国家自然科学基金青年基金项目(No.21102029). 2012-2014.（已结题）

2. 杂原子(氮，氧，硫，硅等)取代的富电子炔烃的反应研究，浙江省自然科学基金一般项目(No. LY14B020013). 2014-2016.（已结题）

3. 钯催化四元环化合物的不对称开环扩环反应，浙江省自然科学基金一般项目(No. LY18B020013). 2018-2020.（在研）

4. 绿色农药茚虫威及其关键中间体的手性合成工艺研究，杭州市自主研究项目(No. 20180432B05). 2018-2020. （在研）

【主要论文著作】（*通讯作者）

Journal papers

1.Yu-Li Sun, Xing-Ben Wang, Feng-Na Sun, Qian-Qian Chen, Jian Cao,* Zheng Xu,* and Li-Wen Xu*, Enantioselective Cross-Exchange between C−I and C−C σ‑Bonds. Angew. Chem. Int. Ed. 2019, 58, 6747.

2. Jian Cao,* Ling Chen, Feng-Na Sun, Yu-Li Sun, Ke-Zhi Jiang, Ke-Fang Yang, Zheng Xu, Li-Wen Xu*, Pd-Catalyzed Enantioselective Ring-Opening/Cross-Coupling and Cyclopropanation of Cyclobutanones. Angew. Chem. Int. Ed. 2019, 58, 897. (Highlighted by Synfacts 2019, 15, 281)

3. Yu-Li Sun, Ling Chen, Jian Cao,* Feng-Na Sun, Zheng Xu, Zhan-Jiang Zheng, Yu-Ming Cui, Li-Wen Xu*. Lewis Acid-Catalyzed Yne-Carbonyl Metathesis of Ynamides and Cyclobutanones: Facile Synthesis of Functionalized Alkylidenecyclobutanes. Asian J. Org. Chem. 2018, 7, 374.

4. Ling Chen, Feng-Na Sun, Yu-Li Sun, Zheng Xu, Zhan-Jiang Zheng, Yu-Ming Cui, Jian Cao,* Li-Wen Xu*. Palladium-Catalyzed Ring-Opening of 2-Alkylidenecyclobutanols: Stereoselective Synthesis of γ,δ-Unsaturated Ketones by C-C Bond Cleavage. Adv. Synth. Catal. 2018, 360, 411.

5. ian Cao,* Zhan-Jiang Zheng, Zheng Xu, Li-Wen Xu*. Transition-metal-catalyzed transfer carbonylation with HCOOH or HCHO as non-gaseous C1 source. Coord. Chem. Rev. 2017, 336, 43.

6. Ling Chen, Yu-Ming Cui, Zheng Xu, Jian Cao,* Zhan-Jiang Zheng, Li-Wen Xu*. An efficient approach toward formation of polycyclic coumarin derivatives via carbocation-initiated [4 + 2] cycloaddition and atom-economic photo-irradiated cyclization. Chem. Commun. 2016, 52, 11131.

7. Ling Chen, Jian Cao,* Zheng Xu, Zhan-Jiang Zheng, Yu-Ming Cui, Li-Wen Xu*. Lewis acid catalyzed [2 + 2] cycloaddition of ynamides and propargyl silyl ethers: synthesis of alkylidenecyclobutenones and their reactivity in ring-opening and ring expansion. Chem. Commun. 2016, 52, 9574.

8. Ling Chen, Lian Yu, Yuan Deng, Zhan-Jiang Zheng, Zheng Xu, Jian Cao,* Li-Wen Xu*. C-H functionalization/C-O bond cleavage of benzyl silyl ethers with ynamides for the chemoselective synthesis of skeletally diverse compounds. Adv. Synth. Catal. 2016, 358, 480.

9. Ling Chen, Lian Yu, Yuan Deng, Yuming Cui, Gaofeng Bian, Jian Cao*. Synthesis of α-haloenamides via zinc halide mediated direct addition of benzhydryl halides to ynamides. Org. Biomol. Chem. 2016, 14, 564.

10. Lian Yu, Yuan Deng, Jian Cao*. Regioselective synthesis of highly substituted imidazoles via the sequential reaction of allenyl sulfonamides and amines. J. Org. Chem. 2015, 80, 4729.

11. Lian Yu, Yuan Deng, Jian Cao*. Synthesis of ketenaminals via catalyst-free hydroamination of ynamides and diphenylsulfonimide. Synthesis 2015, 47, 783.

12. Lian Yu, Jian Cao*. Synthesis of α,β-unsaturated amides and iminocoumarins from N,N-disulfonyl ynamides with aldehydes via the ketenimine intermediate. Org. Biomol. Chem. 2014, 12, 3986.

13. Yulong Kong, Lian Yu, Yuming Cui, Jian Cao*. Synthesis of N-sulfonylamidines by catalyst-free hydroamination of ynamides and amines. Synthesis 2014, 46, 183.

14. Yulong Kong, Kezhi Jiang, Jian Cao,* Lingzi Fu, Lian Yu, Guoqiao Lai, Yuming Cui, Ziqiang Hu, Guanhai Wang. Synthesis of 3-alkyl- or 3-allenyl-2-amidobenzofurans via electrophilic cyclization of o-anisole-substituted ynamides with carbocations. Org. Lett. 2013, 15, 422.

15. Yulong Kong, Lian Yu, Lingzi Fu, Jian Cao,* Guoqiao Lai, Yuming Cui, Ziqiang Hu, Guanhai Wang. Electrophilic cyclization of o-anisole- and o-thioanisole-substituted ynamides: synthesis of 2-amidobenzofurans and 2-amidobenzothiophenes. Synthesis 2013, 45, 1975.

16. Jian Cao,* Yongping Xu, Yulong Kong, Yuming Cui, Ziqiang Hu, Guanhai Wang, Yuan Deng, Guoqiao Lai*. Synthesis of δ-carbolines via a Pd-catalyzed sequential reaction from 2-iodoanilines and N-tosyl-enynamines. Org. Lett. 2012, 14, 38.

17. Jian Cao,* Yulong Kong, Yuan Deng, Guoqiao Lai,* Yuming Cui, Ziqiang Hu, Guanhai Wang. Synthesis of allenamides by Pd-catalyzed coupling of 3-alkoxycarbonyloxy ynamides or 1-alkoxycarbonyloxy allenamides with arylboronic acids. Org. Biomol. Chem. 2012, 10, 9556.

Chapters in books

1. Jian Cao and Li-Wen Xu “Synchronous Application of Hydrocarbons as Solvents and Reagents in Transition-Metal Catalysis”, in Solvents as Reagents in Organic Synthesis, ed: Xiao-Feng Wu, Chapter 11, pp 449-513, 2017, Germany, ISBN 978-3-527-34196-2.

【部分专利】

（1）来国桥，杨雄发，曹 建，邵 倩，杨琳琳，华西林，蒋剑雄，罗蒙贤，一种封装用硅树脂型有机无机杂化材料制备方法，2013.08.28，中国，ZL201110196406

（2）来国桥，杨雄发，杨琳琳，曹 建，邵 倩，蒋剑雄，华西林，一种聚倍半硅氧烷补强的LED封装有机硅橡胶及其制备方法，2013.01.23.中国，ZL201110061714

【联系方式】

欢迎有机化学、化工等相关方向的本科生报考本实验室的研究生！

电话：0571-28867820

电子邮箱：caojian@hznu.edu.cn